Author

M. Filep

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Approach:simulation· 1 Organism:virus· 1

Frequent Co-Authors

D. FearoniD· 2 shared F. von DelftiD· 2 shared N. London· 2 shared A. A. Lee· 1 shared A. von Delft· 1 shared C. Strain-Damerell· 1 shared Covid-Moonshot Consortium· 1 shared D. Owen· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

D. FearonORCID

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2 papers

Recent·Most cited

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor.

D. Zaidman, P. Gehrtz, M. Filep, D. Fearon, J. Prilusky, S. Duberstein, G. Cohen, D. Owen, E. Resnick, C. Strain-Damerell, P. Lukacik, Covid-Moonshot Consortium, H. Barr, M. A. Walsh, F. von Delft, N. London

The paper introduces a computational pipeline to design irreversible inhibitors, identifying a potent SARS-CoV-2 Mpro inhibitor with low micromolar IC50.

Cell Chemical Biology · Dec 1, 2021Peer-reviewedBiochemistry

Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors

M. L. Bobby, D. Fearon, M. Ferla, M. Filep, L. Koekemoer, M. C. Robinson, The COVID Moonshot Consortium, J. D. Chodera, A. A. Lee, N. London, A. von Delft, F. von Delft

The paper describes an open-science drug discovery campaign that identified a non-covalent, non-peptidic inhibitor of SARS-CoV-2 main protease using crowdsourcing and computational methods.

bioRxiv · Oct 29, 2020 · PreprintBiochemistry