Author

M. A. Walsh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:mouse· 1

Frequent Co-Authors

C. Strain-Damerell· 2 shared D. FearoniD· 2 shared E. Resnick· 2 shared F. von DelftiD· 2 shared N. London· 2 shared P. Gehrtz· 2 shared P. Lukacik· 2 shared A. aimon· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

C. Strain-Damerell

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor.

D. Zaidman, P. Gehrtz, M. Filep, D. Fearon, J. Prilusky, S. Duberstein, G. Cohen, D. Owen, E. Resnick, C. Strain-Damerell, P. Lukacik, Covid-Moonshot Consortium, H. Barr, M. A. Walsh, F. von Delft, N. London

The paper introduces a computational pipeline to design irreversible inhibitors, identifying a potent SARS-CoV-2 Mpro inhibitor with low micromolar IC50.

Cell Chemical Biology · Dec 1, 2021Peer-reviewedBiochemistry

EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia.

D. R. Eberhardt, S. H. Lee, X. Yin, A. M. Balynas, E. Rekate, J. N. Kraiss, M. J. Lang, M. A. Walsh, M. E. Streiff, A. C. Corbin, K. Funai, F. B. Sachse, D. Chaudhuri

This study shows that EFHD1 deletion reduces mitochondrial Ca2+ overload and ROS production, protecting cardiomyocytes from ischemia-induced injury.

bioRxiv · Oct 18, 2021Cell Biology

Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal aging

R. V. Musci, K. M. Andrie, M. A. Walsh, Z. J. Valenti, M. F. Afzali, T. E. Johnson, T. E. Kail, R. Martinez, T. Nguyen, J. L. Sanford, M. D. Murrell, J. M. McCord, B. M. Hybertson, B. F. Miller, Q. Zhang, , K. L. Hamilton

This study shows that a Nrf2 activator improves mitochondrial function and proteostasis in aging guinea pigs but does not significantly enhance mobility.

bioRxiv · Jun 11, 2021 · PreprintPhysiology

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

A. Douangamath, D. Fearon, P. Gehrtz, T. Krojer, P. Lukacik, C. D. Owen, E. Resnick, C. Strain-Damerell, A. aimon, P. Abranyi-Balogh, J. Brandao-Neto, A. Carberry, G. Davison, A. Dias, T. D. Downes, , M. A. Walsh

The paper identifies fragment hits against SARS-CoV-2 main protease using crystallography and mass spectrometry, revealing structural insights for drug design.

bioRxiv · May 27, 2020Biophysics

Differential impact on motility and biofilm dispersal of closely related phosphodiesterases in Pseudomonas aeruginosa

Y.-M. Cai, A. Hutchin, J. Craddock, M. A. Walsh, J. S. Webb, I. Tews

This study examines how closely related phosphodiesterases in Pseudomonas aeruginosa affect motility and biofilm dispersal through c-di-GMP regulation.

Scientific Reports · Apr 10, 2020Peer-reviewedMicrobiology