D. Owen

Phospholipid tail asymmetry allows cellular adaptation to anoxic environments

The paper shows that anoxic cells use asymmetric phospholipid acyl-tail length to maintain membrane fluidity, replacing unsaturated species that require oxygen.

Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI.

This paper shows that fibronectin stimulates vascular smooth muscle cells to secrete collagen VI-rich extracellular vesicles that modulate cell adhesion and directionality by forming focal adhesions in the extracellular matrix.

Resilient CD8+ T cells maintain a high cytotoxic capacity by balancing ROS via ME1 upregulation

This paper identifies CX3CR1+ CD8+ T cells with low mitochondrial membrane potential as functionally resilient, showing high cytotoxicity and reduced ROS through ME1 upregulation, which enhances their anti-tumor activity.

Measuring the similarity of SMLM-derived point-clouds

The paper introduces a tool to measure similarity between SMLM-derived point-clouds, distinguishing between conditions and identifying the source of unseen data.

The Cdc42 effector and non-receptor tyrosine kinase, ACK defines a distinct STAT5 transcription signature in a chronic myeloid leukaemia cell model

The paper shows ACK enhances STAT5 transcriptional activity in K562 cells and identifies an ACK-driven STAT5 signature, suggesting a therapeutic target in CML.

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor.

The paper introduces a computational pipeline to design irreversible inhibitors, identifying a potent SARS-CoV-2 Mpro inhibitor with low micromolar IC50.

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

This study identifies PF-00835321 as a potent inhibitor of SARS-CoV-2 3CL protease with in vitro antiviral activity and clinical evaluation potential.

LXR alters CD4+ T cell function through direct regulation of glycosphingolipid synthesis

This study shows LXR regulates glycosphingolipid synthesis in CD4+ T cells, altering lipid balance and reducing plasma membrane order, which dampens pro-inflammatory T cell function.

The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification

The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.

Multi-colour DNA-qPAINT reveals how Csk nano-clusters regulate T-cell receptor signalling

The paper uses DNA-qPAINT to study Csk nano-clusters in T-cells, finding they regulate signaling by re-recruiting after stimulation and interacting with PTPN22.

Differential nanoscale organisation of LFA-1 modulates T cell migration

The paper shows that differential nanoscale organisation of LFA-1 in T-cells modulates migration speed by linking actin flow and signaling.