M. Fraunholz

The AusAB non-ribosomal peptide synthase in Staphylococcus aureus preferentially incorporates exogenous phenylalanine and tyrosine into the aureusimine natural products

This study shows that the Staphylococcus aureus NRPS AusA preferentially uses exogenous phenylalanine and tyrosine for aureusimine biosynthesis, while valine can come from both internal and external sources.

Intracellular Staphylococcus aureus perturbs the host cell Ca2+-homeostasis to promote cell death

This study identifies the calcium signaling pathway as critical for Staphylococcus aureus-induced host cell death through cytosolic and mitochondrial calcium overload.

Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells

This study identifies staphopain A as a cysteine protease used by intracellular Staphylococcus aureus to induce host cell death and enhance bacterial survival during infection.

Armadillo repeat-containing protein 1 is a dual localization protein associated with mitochondrial intermembrane space bridging complex

The paper identifies ArmC1 as a new subunit of the MICOS/MIB complex that localizes to both cytosol and mitochondria, affecting mitochondrial distribution without altering cristae structure or function.