T. Rudel

The AusAB non-ribosomal peptide synthase in Staphylococcus aureus preferentially incorporates exogenous phenylalanine and tyrosine into the aureusimine natural products

This study shows that the Staphylococcus aureus NRPS AusA preferentially uses exogenous phenylalanine and tyrosine for aureusimine biosynthesis, while valine can come from both internal and external sources.

Infection of human organoids supports an intestinal niche for Chlamydia trachomatis

This study infects human intestinal organoids with Chlamydia trachomatis, showing resistance to apical infection and basolateral entry, and identifies Pgp3 as a key virulence factor.

PEGylated recombinant Aplysia punctata ink toxin depletes arginine and lysine and inhibits growth of tumor xenografts

This study shows that PEGylated APIT reduces tumor growth in xenograft models by depleting arginine and lysine through amino acid oxidation.

A central role of sibling sRNAs NgncR_162/163 in main metabolic pathways of Neisseria gonorrhoeae

This study identifies NgncR_162/163 as key regulators of central metabolic pathways in Neisseria gonorrhoeae through transcriptome and metabolome analysis.

c-Myc plays a key role in IFN-γ induced persistence of Chlamydia trachomatis

This study shows that IFN-γ induces Chlamydia persistence by depleting c-Myc, which is regulated by the PI3K-GSK3β axis and L-tryptophan levels, challenging the IDO depletion hypothesis.

Intracellular Staphylococcus aureus perturbs the host cell Ca2+-homeostasis to promote cell death

This study identifies the calcium signaling pathway as critical for Staphylococcus aureus-induced host cell death through cytosolic and mitochondrial calcium overload.

Identification of a novel LysR-type transcriptional regulator in Staphylococcus aureus that is crucial for secondary tissue colonization during metastatic bloodstream infection

Nanoscale imaging of bacterial infections by sphingolipid expansion microscopy

This study uses sphingolipid expansion microscopy to image bacterial infections at nanoscale resolution, revealing details of intracellular bacterial membranes previously only accessible via electron microscopy.

Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells

This study identifies staphopain A as a cysteine protease used by intracellular Staphylococcus aureus to induce host cell death and enhance bacterial survival during infection.

A central role of glutamine in Chlamydia infection

This study identifies glutamine as essential for Chlamydia's EB-RB transition and shows that host glutamine metabolism is reprogrammed to support bacterial growth.