Author

M. Frech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

G. Schett· 2 shared J. Hofmann· 2 shared M. M. Zaiss· 2 shared V. Azizov· 2 shared A. Boger-May· 1 shared A. Favier· 1 shared A. Gessner· 1 shared A. Haghikia· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

G. Schett

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Gut-specific H3R signaling orchestrates microglia-dependent resolution of peripheral inflammation

K. Duerholz, M. Linnerbauer, E. Schmid, H. Danzer, L. Loesslein, L. Amend, L. Ehnes, M. Frech, V. Azizov, F. Schaelter, A. Gessner, S. Lucas, T.-R. Lesker, R. V. Taudte, J. Hofmann, , M. M. Zaiss

The paper identifies gut microbiota-derived histamine as a factor enabling the CNS to suppress peripheral inflammation in RA by activating H3R in the intestine and modulating microglia.

bioRxiv · Jul 11, 2024 · PreprintImmunology

RETINOID ORPHAN RECEPTOR GAMMA T (RORgT) PROMOTES INFLAMMATORY EOSINOPHILIA BUT IS DISPENSABLE FOR INNATE IMMUNE-MEDIATED COLITIS

A. Torres-Huerta, K. Ruley-Haase, T. Reed, A. Boger-May, D. Rubadeux, L. Mayer, A. M. Rajashekara, M. Hiller, M. Frech, C. Roncagli, C. Pedersen, M. C. Camacho, L. Hollmer, L. English, G. Kane, D. Boone

This study shows that RORγt promotes eosinophilia but is not required for innate immune-mediated colitis in TRAG mice.

bioRxiv · Oct 27, 2023Immunology

Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain

F. Henot, E. Rioual, A. Favier, P. Macek, E. Crublet, P. Josso, B. Brutscher, M. Frech, P. Gans, C. Loison, J. Boisbouvier

The paper identifies a metastable excited state in the HSP90 ATP binding domain using solution NMR and mutagenesis, showing it transiently samples a closed state distant from the ground state.

bioRxiv · Mar 16, 2022 · PreprintBiophysics

Alcohol-sourced acetate impairs T cell function by promoting cortactin acetylation

V. Azizov, M. Frech, M. Huebner, J. Hofmann, M. Kubankova, D. Lapuente, M. Tenbusch, J. Guck, G. Schett, M. M. Zaiss

This study shows alcohol-sourced acetate impairs T cell function by promoting cortactin acetylation, which disrupts actin binding and reduces migration and immune responses.

bioRxiv · Mar 8, 2022Immunology