Author

M. G. Durrant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

P. D. Hsu· 2 shared P. Lotfy· 2 shared A. Fanton· 1 shared A. S. Bhatt· 1 shared C. V. Duffy· 1 shared E. Gibson· 1 shared E. Kinnaman· 1 shared E. Wang· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

P. D. Hsu

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2 papers

Recent·Most cited

Large-scale discovery of recombinases for integrating DNA into the human genome

M. G. Durrant, A. Fanton, J. Tycko, M. Hinks, S. S. Chandrasekaran, N. T. Perry, J. Schaepe, P. P. Du, P. Lotfy, M. C. Bassik, L. Bintu, A. S. Bhatt, P. D. Hsu

This paper identifies and validates new large serine recombinases (LSRs) for efficient DNA integration into human genomes, achieving higher efficiency than existing tools.

bioRxiv · Nov 5, 2021Bioengineering

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

J. Wei, P. Lotfy, K. Faizi, S. Baungaard, E. Gibson, E. Wang, H. Slabodkin, E. Kinnaman, S. Chandrasekaran, H. Kitano, M. G. Durrant, C. V. Duffy, P. D. Hsu, S. Konermann

The paper develops a deep learning model to predict CRISPR-Cas13d guide RNA efficiency and identifies novel orthologs with improved specificity and reduced toxicity for RNA targeting.

bioRxiv · Sep 14, 2021Bioengineering