Author

S. Konermann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:genetic perturbation / CRISPR· 2 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

P. D. Hsu· 3 shared J. Wei· 2 shared P. Lotfy· 2 shared A. Ahmed· 1 shared A. M. Sonabend· 1 shared A. Mahajan· 1 shared A. Patil· 1 shared B. Gyorffy· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

P. D. Hsu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses

M. S. Strine, W. L. Cai, J. Wei, M. M. Alfajaro, R. B. Filler, S. B. Biering, S. Sarnik, A. Patil, K. S. Cervantes, C. K. Collings, P. C. DeWeirdt, R. E. Hanna, K. Schofield, C. Hulme, S. Konermann, , C. B. Wilen

This study shows DYRK1A promotes viral entry of SARS-CoV, SARS-CoV-2, and MERS-CoV by regulating ACE2 and DPP4 transcription without its kinase activity.

bioRxiv · Sep 13, 2022 · PreprintMicrobiology

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

J. Wei, P. Lotfy, K. Faizi, S. Baungaard, E. Gibson, E. Wang, H. Slabodkin, E. Kinnaman, S. Chandrasekaran, H. Kitano, M. G. Durrant, C. V. Duffy, P. D. Hsu, S. Konermann

The paper develops a deep learning model to predict CRISPR-Cas13d guide RNA efficiency and identifies novel orthologs with improved specificity and reduced toxicity for RNA targeting.

bioRxiv · Sep 14, 2021Bioengineering

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

C. U. Awah, L. Chen, M. Bansal, A. Mahajan, J. Winter, M. Lad, L. Warnke, E. Gonzalez-Buendia, C. Park, D. Zhang, E. Feldstein, D. Yu, M. Zannikou, I. Balyasnikova, R. Martuscello, , A. M. Sonabend

The paper identifies genes involved in DNA damage response and translation that influence susceptibility to TOP2 poisons in gliomas and other cancers.

bioRxiv · Apr 25, 2019 · PreprintCancer Biology

Structural basis for the RNA-guided ribonuclease activity of CRISPR-Cas13d

C. Zhang, S. Konermann, N. J. Brideau, P. Lotfy, S. J. Novick, T. Strutzenberg, P. R. Griffin, P. D. Hsu, D. Lyumkis

The paper determines the structural basis of CRISPR-Cas13d's RNA-guided ribonuclease activity through cryo-EM and biochemical analysis, revealing its molecular architecture and activation mechanisms.

bioRxiv · May 4, 2018Biochemistry