Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration ofinflammatory immune cells in EGFR mutant lung tumors
D. Ayeni, B. Miller, A. Kuhlmann, P.-C. Ho, C. Robles-Oteiza, M. Gaefele, S. Levy, F. de Miguel, C. Perry, T. Guan, D. Zelterman, R. Homer, Z. Liu, S. Kaech, K. Politi
The paper shows that erlotinib and oncogene withdrawal in EGFR mutant lung tumors increase infiltration of inflammatory immune cells, suggesting immunostimulatory effects of tumor regression.
bioRxiv · Jan 27, 2018Cancer Biology