Author

R. Homer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Iwasaki· 3 shared B. Goldman-Israelow· 3 shared T. Mao· 3 shared A. Suberi· 2 shared D. Ayeni· 2 shared H. Dong· 2 shared K. Politi· 2 shared M. Reschke· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

A. Iwasaki

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination

A. Suberi, M. K. Grun, T. Mao, B. Goldman-Israelow, M. Reschke, J. Grundler, L. Akhtar, T. Lee, K. Shin, A. S. Piotrowski-Daspit, R. Homer, A. Iwasaki, H. W. Suh, W. M. Saltzman

Inhaled polymer nanoparticles deliver mRNA effectively to the lung and induce protective immunity against SARS-CoV-2.

bioRxiv · Mar 22, 2022 · PreprintBioengineering

Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses

T. Mao, B. Goldman-Israelow, A. Suberi, L. Zhou, m. reschke, M. pena-hernandez, H. Dong, R. Homer, M. Saltzman, A. Iwasaki

Unadjuvanted intranasal spike vaccine booster generates broad sarbecovirus protective mucosal immunity in a preclinical model.

bioRxiv · Jan 24, 2022 · PreprintImmunology

Genetic determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo

G. Foggetti, C. Li, H. Cai, J. Hellyer, W.-Y. Lin, D. Ayeni, K. Hastings, J. Choi, A. Wurtz, L. Andrejka, D. Maghini, N. Rashleigh, S. Levy, R. Homer, S. Gettinger, , K. Politi

This study investigates how genetic alterations affect EGFR-driven lung cancer growth and therapy response using a mouse model and CRISPR-Cas9 editing.

Cancer Discovery · Mar 11, 2021Peer-reviewedCancer Biology

Integrated Single Cell Atlas of Endothelial Cells of the Human Lung

J. C. Schupp, T. S. Adams, C. Cosme, M. S. Brickman Raredon, N. Omote, S. Poli, K.-A. Rose, E. Manning, M. Sauler, G. DeIuliis, F. Ahangari, N. Neumark, Y. Yuan, A. C. Habermann, A. J. Gutierrez, , N. Kaminski

The paper reanalyzes six scRNA-seq datasets to create a comprehensive reference atlas of human lung endothelial cells, identifying new subpopulations and confirming their conservation in mice.

bioRxiv · Oct 21, 2020Cell Biology

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

B. Goldman-Israelow, E. Song, T. Mao, P. Lu, A. Meir, F. Liu, M. Madel Alfajaro, J. Wei, H. Dong, R. Homer, A. Ring, C. B. Wilen, A. Iwasaki

This paper develops a mouse model of SARS-CoV-2 using AAV-mediated hACE2 expression, showing type I interferons fail to control viral replication and drive pathology.

bioRxiv · May 27, 2020Immunology

Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration ofinflammatory immune cells in EGFR mutant lung tumors

D. Ayeni, B. Miller, A. Kuhlmann, P.-C. Ho, C. Robles-Oteiza, M. Gaefele, S. Levy, F. de Miguel, C. Perry, T. Guan, D. Zelterman, R. Homer, Z. Liu, S. Kaech, K. Politi

The paper shows that erlotinib and oncogene withdrawal in EGFR mutant lung tumors increase infiltration of inflammatory immune cells, suggesting immunostimulatory effects of tumor regression.

bioRxiv · Jan 27, 2018Cancer Biology