iPSC modeling shows uncompensated mitochondrial mediated oxidative stress underlies early heart failure in hypoplastic left heart syndrome
X. Xu, K. Jin, A. S. Bais, W. Zhu, H. Yagi, T. N. Feinstein, P. Nguyen, J. Criscione, X. Liu, G. Beutner, K. B. Karunakaran, P. Adams, C. K. Kuo, D. Kostka, G. S. Pryhuber, , C. W. Lo
This study uses iPSC-derived cardiomyocytes to show that mitochondrial oxidative stress and ER stress underlie early heart failure in HLHS patients.
bioRxiv · May 9, 2021 · PreprintCell Biology