H. Yagi

The Arabidopsis katamari2 Mutant Exhibits a Hypersensitive Seedling Arrest Response at the Phase Transition from Heterotrophic to Autotrophic Growth

This study shows that Arabidopsis seedlings, including the katamari2 mutant, exhibit a growth arrest response during the phase transition from heterotrophic to autotrophic growth, which is an adaptive stress response rather than a carbon source deficiency.

UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

This study shows UGGT1 reglucosylation competes with EDEM-mediated degradation of misfolded glycoproteins, influencing ER protein quality control.

Hyperactivation of L-lactate oxidase by liquid-liquid phase separation

This study shows that L-lactate oxidase forms liquid droplets that enhance enzyme activity by reducing KM and increasing kcat, representing the first report of increased kcat through droplet formation.

Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

This study shows that inverse agonist activity of angiotensin II receptor blockers is essential for preventing aortic aneurysm formation in Marfan syndrome mice.

Orchestration of Proteins in cyanobacterial Circadian Clock System 1

This study reveals that the cyanobacterial circadian clock involves synchronized multiple association-dissociation reactions between Kai proteins, not a single process as previously thought.

Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

This study identifies aberrant mechanosensitive signaling in vascular endothelial cells as a driver of xanthine oxidoreductase activation and ROS generation, contributing to aortic aneurysm formation in Marfan syndrome.

Cancer malignancy is correlated with up-regulation of PCYT2-mediated glycerol phosphate modification of α-dystroglycan

This study shows that PCYT2-mediated glycerol phosphate modification of α-dystroglycan correlates with cancer progression and promotes cell migration in colorectal cancer.

iPSC modeling shows uncompensated mitochondrial mediated oxidative stress underlies early heart failure in hypoplastic left heart syndrome

This study uses iPSC-derived cardiomyocytes to show that mitochondrial oxidative stress and ER stress underlie early heart failure in HLHS patients.

Multi-state structure determination and dynamics analysis reveals a new ubiquitin-recognition mechanism in yeast ubiquitin C-terminal hydrolase

The paper develops an NMR method to determine multi-state structures of proteins and applies it to yeast ubiquitin hydrolase 1, revealing dynamic motions critical for ubiquitin recognition and proteolysis.