Ebola Virus VP35 Interacts Non-Covalently with Ubiquitin Chains to Promote Viral Replication Creating New Therapeutic Opportunities
C. A. Rodriguez-Salazar, S. van Tol, O. Mailhot, G. T. Galdino, N. F. Borges Teruel, L. Zhang, A. N. Warren, M. Gonzalez-Orozco, A. N. Freiberg, R. J. Najmanovich, M. I. Giraldo, R. Rajsbaum
This study identifies a non-covalent interaction between Ebola virus VP35 and ubiquitin chains that supports viral replication and discovers compounds that block this interaction to reduce viral activity.
bioRxiv · Jul 14, 2023 · PreprintImmunology