Author

A. N. Freiberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Organism:mouse· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

B. A. Johnson· 3 shared B. Kalveram· 3 shared B. Lee· 3 shared J. A. Plante· 3 shared R. Rajsbaum· 3 shared V. D. Menachery· 3 shared C. Atkins· 2 shared J. E. Comer· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

B. A. Johnson

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Tetracistronic Minigenomes Elucidate a Functional Promoter for Ghana Virus and Unveils Cedar Virus Replicase Promiscuity for all Henipaviruses

G. D. Haas, K. S. Schmitz, K. D. Azarm, K. N. Johnson, W. R. Klain, A. N. Freiberg, R. M. Cox, R. K. Plemper, B. Lee

This paper develops tetracistronic minigenomes for henipaviruses to model their life cycle outside high biocontainment, revealing Cedar virus replicase promiscuity and functional GhV replicase with antiviral efficacy.

Journal of Virology · Oct 22, 2024Peer-reviewedMicrobiology

Ebola Virus VP35 Interacts Non-Covalently with Ubiquitin Chains to Promote Viral Replication Creating New Therapeutic Opportunities

C. A. Rodriguez-Salazar, S. van Tol, O. Mailhot, G. T. Galdino, N. F. Borges Teruel, L. Zhang, A. N. Warren, M. Gonzalez-Orozco, A. N. Freiberg, R. J. Najmanovich, M. I. Giraldo, R. Rajsbaum

This study identifies a non-covalent interaction between Ebola virus VP35 and ubiquitin chains that supports viral replication and discovers compounds that block this interaction to reduce viral activity.

bioRxiv · Jul 14, 2023 · PreprintImmunology

The Prophylactic and Therapeutic Efficacy of the Broadly Active Antiviral Ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a Mouse Model of Lethal Ebola Virus Infection

G. R. Bluemling, S. Mao, M. G. Natchus, W. Painter, S. Mulangu, M. Lockwood, A. D. L. R. De La Rosa, T. Brasel, J. E. Comer, A. N. Freiberg, A. Kolykhalov, G. R. Painter

This study evaluates the efficacy of EIDD-1931, a ribonucleoside analog, in preventing and treating lethal Ebola virus infection in mice.

bioRxiv · Oct 18, 2022 · PreprintMicrobiology

Nipah virus Bangladesh infection elicits organ-specific innate and inflammatory responses in the marmoset model

C. S. Stevens, J. Lowry, T. Juelich, C. Atkins, K. Johnson, J. K. Smith, M. Panis, T. Ikegame, B. tenOever, A. N. Freiberg, B. Lee

This study investigates NiV Bangladesh infection in marmosets, revealing organ-specific innate and inflammatory responses through RNA-seq analysis.

bioRxiv · Oct 11, 2021Microbiology

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

J. A. Plante, Y. Liu, J. Liu, H. Xia, B. A. Johnson, K. G. Lokugamage, X. Zhang, A. E. Muruato, J. Zou, C. R. Fontes-Garfias, D. Mirchandani, D. Scharton, J. P. Bilello, Z. Ku, Z. An, , P.-Y. Shi

This study shows the D614G mutation in SARS-CoV-2 increases viral replication and upper respiratory tract viral loads but does not reduce vaccine efficacy or antibody neutralization.

bioRxiv · Sep 1, 2020Microbiology

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

B. A. Johnson, X. Xie, B. Kalveram, K. G. Lokugamage, A. Muruato, J. Zou, X. Zhang, T. Juelich, J. K. Smith, L. Zhang, C. Schindewolf, M. N. Vu, A. Vanderheiden, J. A. Plante, K. S. Plante, , V. D. Menachery

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

bioRxiv · Aug 26, 2020 · PreprintMicrobiology

Pyronaridine Tetraphosphate Efficacy Against Ebola Virus Infection in Guinea Pig

T. R. Lane, C. Massey, J. E. Comer, A. N. Freiberg, H. Zhou, J. Dyall, M. Holbrook, M. Anantpadma, R. A. Davey, P. Madrid, S. Ekins

This paper evaluates pyronaridine tetraphosphate's efficacy against Ebola and Marburg viruses in guinea pigs, showing 40% survival and suggesting its potential for antiviral repurposing.

bioRxiv · Mar 20, 2020Pharmacology & Toxicology

VAMP8 contributes to TRIM6-mediated type-I interferon antiviral response during West Nile virus infection

C. Atkins, S. Van Tol, P. Bharaj, R. Rajsbaum, A. N. Freiberg

This paper identifies VAMP8 as a novel gene regulated by TRIM6 that enhances IFN-I signaling and restricts WNV replication in human cells.

Journal of Virology · Jan 6, 2020Peer-reviewedImmunology

Peptidoglycan associated cyclic lipopeptide disrupts viral infectivity

B. A. Johnson, A. Hage, B. Kalveram, M. Mears, J. A. Plante, S. E. Rodriguez, Z. Ding, X. Luo, D. Bente, S. S. Bradrick, A. N. Freiberg, V. Popov, R. Rajsbaum, S. Rossi, W. K. Russell, V. D. Menachery

The paper identifies surfactin, a cyclic lipopeptide from bacterial peptidoglycan, as a broad-spectrum virucidal compound that disrupts enveloped virus infectivity.

bioRxiv · May 13, 2019Microbiology