Flexible RSV prefusogenic fusion glycoprotein exposes multiple neutralizing epitopes that may collectively contribute to protective immunity
N. Natel, J.-H. Tian, R. Flores, K. Jacobson, M. Walker, A. Portnoff, M. Gueber-Xabier, M. J. Massare, G. Glenn, L. R. Ellingsworth, G. Smith
This study compares the immunogenicity of native prefusogenic RSV F glycoprotein variants in animal models, finding that native F elicits broader neutralizing antibodies targeting multiple epitopes compared to variants with structural modifications.
bioRxiv · Sep 14, 2020Immunology