Author

J.-H. Tian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 3 Cancer Biology· 1 Ecology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 9 Research Focus:drug response / drug discovery· 5 Assay:proteomics· 5 Assay:metagenomics· 4 Organism:mouse· 4 Organism:non-human primate· 4 Organism:human· 3

Frequent Co-Authors

G. Glenn· 7 shared G. Smith· 7 shared M. J. Massare· 6 shared N. Patel· 6 shared A. D. Portnoff· 5 shared B. Zhou· 5 shared M. Guebre-Xabier· 5 shared S. Maciejewski· 5 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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7 shared papersImmunology

G. Glenn

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

Y.-f. Pan, H. Zhao, Q.-y. Gou, P.-b. Shi, J.-h. Tian, Y. Feng, K. Li, W.-h. Yang, D. Wu, G. Tang, B. Zhang, Z. Ren, S. Peng, G.-y. Luo, S.-j. Le, , M. Shi

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

bioRxiv · Aug 28, 2023 · PreprintEcology

Using artificial intelligence to document the hidden RNA virosphere

X. Hou, Y. He, P. Fang, S.-Q. Mei, Z. Xu, W.-C. Wu, J.-H. Tian, S. Zhang, Z.-Y. Zeng, Q.-Y. Gou, G.-Y. Xin, S.-J. Le, Y.-Y. Xia, Y.-L. Zhou, F.-M. Hui, , M. Shi

This study uses a deep learning algorithm to discover highly divergent RNA viruses in metatranscriptomes, identifying 161,979 potential species and 180 supergroups.

bioRxiv · Apr 18, 2023Microbiology

Immunogenicity and In vivo protection of a variant nanoparticle vaccine that confers broad protection against emerging SARS-CoV-2 variants

J. Logue, R. Johnson, N. Patel, B. Zhou, S. Maciejewski, H. Zhou, A. Portnoff, J.-H. Tian, M. McGrath, R. Haupt, S. Weston, H. Hammod, M. Guebre-Xabier, C. Dillen, J. Plested, , M. Frieman

This study evaluates a nanoparticle vaccine against SARS-CoV-2 variants, showing it induces strong immune responses and protection in mice and baboons against multiple variants.

bioRxiv · Jun 8, 2021 · PreprintImmunology

Combination Respiratory Vaccine Containing Recombinant SARS-CoV-2 Spike and QuadrivalentSeasonal Influenza Hemagglutinin Nanoparticles with Matrix-M Adjuvant

M. J. Massare, N. Patel, B. Zhou, S. Maciejewski, R. Flores, M. Guebre-Xabier, J.-H. Tian, A. D. Portnoff, L. Fries, V. Shinde, L. R. Ellingsworth, G. Glenn, G. Smith

This paper evaluates a combination vaccine against seasonal influenza and SARS-CoV-2 in animal models, showing it induces protective immune responses and prevents viral replication and disease.

bioRxiv · May 5, 2021 · PreprintImmunology

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination

M. J. Gorman, N. Patel, M. Guebre-Xabier, A. Zhu, C. Atyeo, K. Pullen, C. Loos, Y. Goez-Gazi, R. Carrion, J.-H. Tian, D. Yuan, K. Bowman, B. Zhou, S. Maciejewski, M. McGrath, , G. Alter

This study shows that NVX-CoV2373 vaccine induces antibodies with both neutralizing and Fc-effector functions, which together provide maximal protection against SARS-CoV-2 in non-human primates.

bioRxiv · Feb 5, 2021 · PreprintImmunology

Flexible RSV prefusogenic fusion glycoprotein exposes multiple neutralizing epitopes that may collectively contribute to protective immunity

N. Natel, J.-H. Tian, R. Flores, K. Jacobson, M. Walker, A. Portnoff, M. Gueber-Xabier, M. J. Massare, G. Glenn, L. R. Ellingsworth, G. Smith

This study compares the immunogenicity of native prefusogenic RSV F glycoprotein variants in animal models, finding that native F elicits broader neutralizing antibodies targeting multiple epitopes compared to variants with structural modifications.

bioRxiv · Sep 14, 2020Immunology

NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

M. Guebre-Xabier, N. Patel, J.-H. Tian, B. Zhou, S. Maciejewski, K. Lam, A. D. Portnoff, M. J. Massare, M. B. Frieman, P. A. Piedra, L. R. Ellingsworth, G. Glenn, G. Smith

This study evaluates the NVX-CoV2373 vaccine in cynomolgus macaques, showing it induces neutralizing antibodies and protects against SARS-CoV-2 infection in upper and lower airways.

bioRxiv · Aug 18, 2020Immunology

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

S. Bangaru, G. Ozorowski, H. L. Turner, A. Antanasijevic, D. Huang, X. Wang, J. L. Torres, J. K. Diedrich, J.-H. Tian, A. D. Portnoff, N. Patel, M. J. Massare, J. R. Yates, D. Nemazee, J. C. Paulson, , A. B. Ward

The paper uses cryo-EM and glycan analysis to study the structure of a full-length SARS-CoV-2 spike protein in a vaccine candidate, revealing its stable prefusion conformation and novel trimer interactions.

bioRxiv · Aug 6, 2020Immunology

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice

J.-H. Tian, N. Patel, R. Haupt, H. Zhou, S. Weston, H. Hammond, J. Lague, A. D. Portnoff, J. Norton, M. Guebre-Xabier, B. Zhou, K. Jacobson, S. Maciejewski, R. Khatoon, M. Wisniewska, , G. Smith

This study evaluates the immunogenicity and protective efficacy of the NVX-CoV2373 SARS-CoV-2 vaccine in baboons and mice, showing strong immune responses and protection without enhanced disease.

bioRxiv · Jun 29, 2020Microbiology

Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China

F. Wu, S. Zhao, B. Yu, Y.-M. Chen, W. Wang, Y. Hu, Z.-G. Song, Z.-W. Tao, J.-H. Tian, Y.-Y. Pei, M.-L. Yuan, Y.-L. Zhang, F.-H. Dai, Y. Liu, Q.-M. Wang, , Y.-Z. Zhang

The paper characterizes the complete genome of a novel coronavirus, WHCV, linked to a respiratory outbreak in Wuhan, finding it closely related to SARS-like bat coronaviruses.

bioRxiv · Jan 24, 2020 · PreprintPathology

Upscaling of Microbial Electrolysis Cell Integrating Microbial Electrosynthesis: Insights, Challenges and Perspectives

J.-H. Tian, R. Lacroix, E. Desmond-Le Quemener, C. Bureau, C. Midoux, T. Bouchez

This study designs and evaluates a 15-liter microbial electrolysis cell for microbial electrosynthesis, achieving high COD removal and acetate production while addressing bioanode sustainability.

bioRxiv · Apr 16, 2019 · PreprintMicrobiology

Influence of miR-520e-mediated MAPK signaling pathway on HBV replication and regulation of hepatocellular carcinoma cells via targeting EphA2

J.-h. Tian, W.-d. Liu, Z.-y. Zhang, L.-h. Tang, D. Li, Z.-j. Tian, S.-w. Lin, Y.-j. Li

This study shows miR-520e inhibits HBV replication and HCC cell growth by suppressing EphA2 and the MAPK pathway.

bioRxiv · Jun 7, 2018Cancer Biology