R. Flores

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.

Combination Respiratory Vaccine Containing Recombinant SARS-CoV-2 Spike and QuadrivalentSeasonal Influenza Hemagglutinin Nanoparticles with Matrix-M Adjuvant

This paper evaluates a combination vaccine against seasonal influenza and SARS-CoV-2 in animal models, showing it induces protective immune responses and prevents viral replication and disease.

Flexible RSV prefusogenic fusion glycoprotein exposes multiple neutralizing epitopes that may collectively contribute to protective immunity

This study compares the immunogenicity of native prefusogenic RSV F glycoprotein variants in animal models, finding that native F elicits broader neutralizing antibodies targeting multiple epitopes compared to variants with structural modifications.

CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with tumor antigen load and TP53 mutations

The paper analyzes CITEseq data from NSCLC lesions to identify an immune cell activation module linked to tumor antigen load and TP53 mutations.

Holobiont Urbanism: sampling urban beehives reveals cities' metagenomes

This study uses urban beehives to sample city metagenomes, finding bee debris as the richest substrate, and discusses applications for epidemic surveillance.

Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism

This paper shows that the aneural protist Physarum polycephalum uses mechanosensation to preferentially grow toward heavier, chemically inert masses, revealing a novel biomechanical decision-making mechanism.