Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities
J. H. Rogers, R. Gupta, J. M. Reyes, M. Gundry, G. Medrano, A. Guzman, T. Song, C. Johnson, S. Barnes, C. D. D. Cristobal, L. Brunetti, M. A. Goodell, R. E. Rau
This study models IKZF1 lesions in B-ALL to show distinct chemosensitivity patterns and therapeutic vulnerabilities, identifying cytarabine sensitivity and JAK/STAT upregulation as potential targets.
bioRxiv · May 26, 2020Cancer Biology