T. Song

Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth

This study identifies sMyBP-C's critical role in skeletal muscle development and function using gene-edited mouse models, showing its necessity for prenatal and postnatal muscle growth and structural integrity.

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.

This study investigates the effects of MyBP-C knockout in skeletal muscle, finding altered length-dependent activation and myofilament structure, with implications for MyBP-C-related diseases.

The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states.

This study decouples structural OFF/ON states from biochemical SRX/DRX states in myosin using X-ray diffraction and ATP assays in porcine myocardium.

Camouflaging Endovascular Stents with an Endothelial Coat Using CD31 Domain 1-mimetic Peptides

This study coats endovascular stents with CD31 domain 1-mimetic peptides to promote endothelial integration and reduce blood cell activation, showing improved device integration and neo-arterial wall formation over 60 days.

Sulfur oxidation and reduction are coupled to nitrogen fixation in the roots of a salt marsh foundation plant species

This study shows sulfur oxidation and reduction are coupled to nitrogen fixation in the roots of Spartina alterniflora, with a novel symbiosis involving Candidatus Thiodiazotropha.

Designer DNA NanoGripper

The paper designs, synthesizes, and characterizes a DNA nanorobot, NanoGripper, capable of capturing viral particles and functioning as a biosensor for SARS-CoV-2 detection in human saliva.

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

Target Recycling Amplification Process for Digital Detection of Exosomal MicroRNAs Through Photonic Resonator Absorption Microscopy

This paper introduces TRAP, a method for detecting exosomal miRNAs with high sensitivity and selectivity, showing improved detection limits compared to qRT-PCR.

Interactions between culturable bacteria are highly non-additive

The paper examines how multiple bacterial species interact with a focal species, finding that community effects are non-additive and dominated by the strongest individual effect.

Galectin-8 is a major ligand of LILRB4 prompting MDSC functions in the tumor microenvironment

This study identifies Galectin-8 as a functional ligand of LILRB4 that promotes MDSC expansion and tumor growth, suggesting its blockade as a potential immunotherapy strategy.

Machine learning analysis reveals the dynamics of mode transition in dendritic cell migration

This study uses machine learning to analyze dendritic cell migration patterns and identifies three distinct motility modes and their transitions during maturation.

Exosomal miR-106b-5p promotes Mtb survival via targeting CREB5 followed by SOAT1-CIDEC and CASP9-CASP3 pathway

The paper identifies miR-106b-5p in exosomes from Mtb-infected macrophages that promote Mtb survival by regulating lipid metabolism and apoptosis in uninfected macrophages.

The core root microbiome of Spartina alterniflora is predominated by sulfur-oxidizing and sulfate-reducing bacteria in Georgia salt marshes, USA

This study examines the root microbiome of Spartina alterniflora in Georgia salt marshes, finding sulfur-oxidizing and sulfate-reducing bacteria dominate and are linked to plant productivity.

Rpi-amr3 confers resistance to multiple Phytophthora species by recognizing a conserved RXLR effector

The paper identifies Rpi-amr3 as a resistance gene that recognizes a conserved RXLR effector from multiple Phytophthora species, conferring broad resistance.

Molecular basis and evolutionary cost of a novel phenotype of macrolides/lincosamides resistance in Staphylococcus haemolyticus

This study identifies a novel constitutive MLS resistance in S. haemolyticus and shows that ErmC deletion causes resistance while continuous ErmC expression imposes a growth cost.

Spatial transcriptome sequencing revealed spatial trajectory in the Non-Small Cell Lung Carcinoma

The paper uses spatial transcriptomics to analyze lung cancer heterogeneity, identifying gene expression gradients and tumor subclones, and infers metastasis trajectories through pseudo-time modeling.

Binding strength and hydrogen bond numbers between Covid-19 RBD and HVR of antibody

This paper uses infrared spectroscopy to analyze the temperature-dependent hydrogen bonding between SARS-CoV-2 RBD and antibodies, finding increased binding strength at higher temperatures.

Integrative identification by Hi-C revealed distinct advanced structural variations in Lung Adenocarcinoma tissue

This study uses Hi-C to identify structural variations in lung adenocarcinoma tissues, revealing compartment shifts, TADs, and enhancer-promoter loops associated with key genes on chromosome 3.

Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities

This study models IKZF1 lesions in B-ALL to show distinct chemosensitivity patterns and therapeutic vulnerabilities, identifying cytarabine sensitivity and JAK/STAT upregulation as potential targets.

A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector

The paper identifies a new R gene, Rpi-amr1, from Solanum americanum that provides broad-spectrum resistance to Phytophthora infestans and defines its allelic diversity.

Microbial composition of the human nasopharynx varies according to influenza virus type and vaccination status.

The paper examines how influenza virus type and vaccination status influence nasopharyngeal microbiota composition in infected individuals and healthy controls.

Different subtypes of influenza A viruses target different human proteins and pathways leading to different pathogenic phenotypes

This study identifies subtype-specific influenza A virus-host protein interactions that correlate with different pathogenic outcomes.

Rice annexin OsANN4 interacting with OsCDPK24, reduces root aerenchyma formation by modulating H2O2 under ABA treatment

The paper identifies OsANN4 as a rice annexin that interacts with OsCDPK24, modulates H2O2 levels, and affects root aerenchyma formation under ABA treatment.

Efficient genome editing of Magnetospirillum magneticum AMB-1 by CRISPR-Cas9 system for analyzing magnetotactic behavior

This study uses CRISPR-Cas9 to efficiently edit the Magnetospirillum magneticum AMB-1 genome, revealing Amb0994's role in magnetotactic behavior through flagellar control.