Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA clusters in cancer
E. Yi, A. D. Gujar, M. Guthrie, H. Kim, K. C. Johnson, S. B. Amin, S. Das, P. A. Clow, A. W. Cheng, R. G. Verhaak
The paper uses live-cell imaging to show uneven ecDNA segregation and transcriptional clustering in cancer cells, explaining ecDNA accumulation and oncogenesis.
bioRxiv · Oct 20, 2020 · PreprintCancer Biology