Author

A. W. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Approach:genetic perturbation / CRISPR· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

N. Jillette· 5 shared J. J. Zhu· 3 shared A. D. Gujar· 1 shared C. C. Lau· 1 shared C. Ople· 1 shared D. A. Faddah· 1 shared E. Kulenkampff· 1 shared E. Yi· 1 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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5 shared papersBioengineering

N. Jillette

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Simultaneous multifunctional transcriptome engineering by CRISPR RNA scaffold

Z. Liu, P. Robson, A. W. Cheng

This paper introduces CREST, a CRISPR-based platform that enables simultaneous RNA modulation functions, reducing off-target effects and expanding transcriptome engineering capabilities.

bioRxiv · Jun 21, 2022Bioengineering

Targeted directional kilobase sequence insertion by combining prime editing with recombinases or integrases

N. Jillette, J. J. Zhu, A. W. Cheng

This paper introduces PRIMAS, a method combining prime editing with recombinases/integrases to insert kilobase sequences directionally into genomes.

bioRxiv · May 25, 2022 · PreprintBioengineering

Fibroblasts-derived from Pluripotent Cells Harboring a Single Allele Knockout in Two Pluripotency Genes Exhibit DNA Methylation Abnormalities and pluripotency induction Defects

R. Lasry, N. Maoz, A. W. Cheng, N. Yom Tov, E. Kulenkampff, M. Azagury, H. Yang, C. Ople, S. Markoulaki, D. A. Faddah, K. Makedonski, O. Sabbag, R. Jaenisch, Y. Buganim

This study shows that fibroblasts from pluripotent cells with single-allele knockouts in two pluripotency genes have DNA methylation issues and reduced pluripotency induction ability.

bioRxiv · May 18, 2022 · PreprintCell Biology

Local recruitment of DNA repair proteins enhances CRISPR-ssODN-HDR editing

N. Jillette, J. J. Zhu, A. W. Cheng

This study enhances CRISPR-ssODN-HDR editing by recruiting DNA repair proteins to Cas9 cut sites using two strategies, increasing precise edits.

bioRxiv · Apr 13, 2022 · PreprintBioengineering

Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA clusters in cancer

E. Yi, A. D. Gujar, M. Guthrie, H. Kim, K. C. Johnson, S. B. Amin, S. Das, P. A. Clow, A. W. Cheng, R. G. Verhaak

The paper uses live-cell imaging to show uneven ecDNA segregation and transcriptional clustering in cancer cells, explaining ecDNA accumulation and oncogenesis.

bioRxiv · Oct 20, 2020 · PreprintCancer Biology

C11orf95-RELA Reprograms 3D Epigenome in Supratentorial Ependymoma

J. J. Zhu, N. Jillette, X.-N. Li, A. W. Cheng, C. C. Lau

This study investigates how the C11orf95-RELA fusion protein reprograms the 3D epigenome in supratentorial ependymoma, revealing its role in chromatin state modulation and transcriptional reprogramming.

bioRxiv · Jun 4, 2020Cancer Biology

Split Selectable Markers

N. Jillette, M. Du, A. W. Cheng

This paper introduces split selectable markers to enable selection of multiple unlinked transgenes in lentiviral transgenesis and CRISPR/Cas biallelic knock-ins.

bioRxiv · Jan 23, 2019Bioengineering

CRISPR Artificial Splicing Factors

N. Jillette, A. W. Cheng

This paper engineers CRISPR Artificial Splicing Factors (CASFx) to control alternative splicing through differential positioning and inducible systems.

bioRxiv · Sep 30, 2018Bioengineering