J. J. Enghild

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring

This study uses cryo-EM to analyze the structural changes in C3 during hydrolysis, revealing a dynamic opening in the macroglobulin ring that allows domain translocation.

APP and its intracellular domain modulate Alzheimers disease risk gene networks in transgenic APPsw and PSEN1M146I porcine models

This study uses transgenic porcine models to show that APP and its AICD domain modulate AD-related gene networks through interactions with signaling proteins.

Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan- hyaladherin interactions.

This study chemically modifies HA oligosaccharides to differentially modulate their binding to HABPs, revealing structural insights into HA-receptor interactions.

Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase

This study reveals how PhnJ mediates ATP hydrolysis-induced structural changes in the C-P lyase complex, uncovering a novel ABC dimer configuration.

Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets

This study identifies the ligandome of LRP1 in cartilage using a top-down approach, revealing novel ligands and their role in osteoarthritis.

The essential Porphyromonas gingivalis type IX secretion system component PorZ delivers anionic-lipopolysaccharide to the PorU sortase for transpeptidase processing of cargos

This paper identifies PorZ as a T9SS component that binds anionic lipopolysaccharide (A-LPS) and interacts with the PorU sortase to facilitate cargo protein anchoring to the outer membrane.

Kallikrein-related peptidase 14 activates zymogens of membrane type matrix metalloproteinases (MT-MMPs) - a CleavEx library-based analysis

This study identifies KLK14 as a specific activator of proMT-MMPs using a CleavEx library-based approach, revealing its role in ECM remodeling and potential implications in cancer.

Tracing the in Vivo Fate of Nanoparticles with a "Non-Self" Biological Identity

The paper investigates the in vivo fate of nanoparticles with a non-self protein corona in zebrafish embryos, showing rapid sequestration and inflammatory effects.

Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association

This study identifies soft corona proteins on nanoparticles and shows their role in modulating nanoparticle-cell association despite weak interactions.

Heavy chain-1 of inter-α-inhibitor has an integrin-like structure with immune regulatory activities

This paper identifies HC1 of inter-α-inhibitor as having an integrin-like structure with immune regulatory functions through inhibition of the alternative pathway C3 convertase.