Author

M. Hasipek

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. M. Zidan· 1 shared B. Hamilton· 1 shared B. K. Jha· 1 shared B. Tomlinson· 1 shared C. Hong· 1 shared C. Schuerger· 1 shared E. D. Hsi· 1 shared H. Carraway· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. M. Zidan

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1 paper

Recent·Most cited

Resistance to decitabine and 5-azacytidine emerges from adaptive responses of the pyrimidine metabolism network

X. Gu, R. Tohme, B. Tomlinson, M. Hasipek, L. Durkin, C. Schuerger, A. M. Zidan, T. Radivoyevitch, C. Hong, H. Carraway, B. Hamilton, R. Sobecks, B. K. Jha, E. D. Hsi, J. Maciejewski, Y. Saunthararajah

This paper identifies adaptive metabolic responses in pyrimidine metabolism as a mechanism of resistance to decitabine and 5-azacytidine, and shows that alternating these drugs with metabolic inhibitors can extend DNMT1 depletion and delay leukemia relapse.

bioRxiv · Feb 20, 2020Cancer Biology