Author

B. K. Jha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Berezovsky· 1 shared A. M. Zidan· 1 shared B. A. Bell· 1 shared B. Hamilton· 1 shared B. Przychodzen· 1 shared B. Tomlinson· 1 shared C. Hong· 1 shared C. Schuerger· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Berezovsky

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2 papers

Recent·Most cited

Resistance to decitabine and 5-azacytidine emerges from adaptive responses of the pyrimidine metabolism network

X. Gu, R. Tohme, B. Tomlinson, M. Hasipek, L. Durkin, C. Schuerger, A. M. Zidan, T. Radivoyevitch, C. Hong, H. Carraway, B. Hamilton, R. Sobecks, B. K. Jha, E. D. Hsi, J. Maciejewski, Y. Saunthararajah

This paper identifies adaptive metabolic responses in pyrimidine metabolism as a mechanism of resistance to decitabine and 5-azacytidine, and shows that alternating these drugs with metabolic inhibitors can extend DNMT1 depletion and delay leukemia relapse.

bioRxiv · Feb 20, 2020Cancer Biology

Development of a Cx46 targeting strategy for cancer stem cells

E. E. Mulkearns-Hubert, L. A. Torre-Healy, D. J. Silver, J. T. Eurich, E. Serbinowski, M. Hitomi, J. Zhou, B. Przychodzen, R. Zhang, S. A. Sprowls, J. S. Hale, T. Alban, A. Berezovsky, B. A. Bell, P. R. Lockman, , J. D. Lathia

This study identifies clofazimine as a Cx46 inhibitor that targets glioblastoma cancer stem cells by disrupting gap junction communication, enhancing the efficacy of temozolomide.

bioRxiv · Mar 26, 2018Cancer Biology