Author

M. Hughson Frederick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Daisy Castillo-GuzmaniD· 1 shared Frederic L. ChediniD· 1 shared Lionel A. SanziD· 1 shared Stella R. HartonoiD· 1 shared Tadas SereivaiD· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperMolecular Biology

Daisy Castillo-GuzmanORCID

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1 paper

Recent·Most cited

SF3B1-targeted Splicing Inhibition Triggers Transcriptional Stress Response and Global Alterations in R-Loop Landscape

Daisy Castillo-Guzman, Stella R. Hartono, M. Hughson Frederick, Lionel A. Sanz, Tadas Sereiva, Frederic L. Chedin

This study shows that SF3B1 inhibition causes intron retention and R-loop changes, with R-loop gains linked to stress-response gene readthrough and not DNA damage.

bioRxiv · Jun 8, 2020 · PreprintMolecular Biology