Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair
P. Niekamp, T. Sokoya, L. Vittadello, Y. Deng, Y. Kim, A. Hilderink, M. Imlau, C. J. Clarke, C. G. Burd, J. C. M. Holthuis
The paper identifies a Ca2+-activated sphingomyelin scrambling pathway that mediates ESCRT-independent lysosomal repair by converting sphingomyelin into repair intermediates.
bioRxiv · Mar 12, 2021Cell Biology