Author

R. H. A. M. Vossen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Harmanus· 2 shared E. J. Kuijper· 2 shared Q. R. Ducarmon· 2 shared S. L. Kloet· 2 shared W. K. Smits· 2 shared A. C. Fluit· 1 shared A. M. Roseboom· 1 shared B. A. L. M. Deiman· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

C. Harmanus

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 17, 2022

Clostridioides difficile PCR ribotype 151 is polyphyletic and includes pathogenic isolates from cryptic clade C-II with mono-toxin pathogenicity loci that can escape routine diagnostics

Q. R. Ducarmon, T. van der Bruggen, C. Harmanus…·W. K. Smits

The paper identifies that PCR ribotype 151 of Clostridioides difficile is polyphyletic, includes both non-toxigenic and toxigenic isolates, and contains pathogenic variants that evade routine diagnostics.

DOI 10.1101/2022.08.17.504118

viruswhole-genome sequencing

𝕏 PostBluesky

MicrobiologybioRxivJul 10, 2022

Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile

A. M. Roseboom, Q. R. Ducarmon, B. V. H. Hornung…·W. K. Smits

The paper describes a C. difficile clinical isolate carrying three compatible plasmids and identifies functional replicons in two of them.

DOI 10.1016/j.plasmid.2022.102669

C. eleganswhole-genome sequencing

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivMar 2, 2020

A unifying model to predict variable drug response for personalised medicine

M. van der Lee, W. G. Allard, R. H. A. M. Vossen…·S. Y. Anvar

The paper introduces a continuous scale model using full gene sequencing and neural networks to predict CYP2D6 enzyme activity, explaining 79% of interindividual variability in drug response.

DOI 10.1126/scitranslmed.abf3637

humanwhole-exome sequencing

𝕏 PostBluesky