Author

M. J. Dominguez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:protein structure· 2 Approach:contrastive learning· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

R. B. Sutton· 2 shared A. H. Carhart· 1 shared A. J. Adkins· 1 shared A. Snow· 1 shared B. J. Lantz· 1 shared E. J. Stollar· 1 shared E. Masoumzadeh· 1 shared F. M. Harsini· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

R. B. Sutton

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pathogenic Mutations in the C2A Domain of Dysferlin form Amyloid that Activates the Inflammasome.

I. L. Scott, M. J. Dominguez, A. Snow, F. M. Harsini, J. Williams, K. L. Fuson, R. Thapa, P. Bhattacharjee, G. A. Cornwall, P. A. Keyel, R. B. Sutton

This study shows that C2A domain mutations in dysferlin cause amyloid formation, which activates the NLRP3 inflammasome and leads to inflammation and muscle dysfunction in Limb-Girdle Muscular Dystrophy Type-2B/2R.

bioRxiv · Apr 24, 2023 · PreprintBiophysics

How a highly acidic SH3 domain folds in the absence of its charged peptide target

V. Jaramillo- Martinez, M. J. Dominguez, G. M. Bell, M. E. Souness, A. H. Carhart, M. A. Cuibus, E. Masoumzadeh, B. J. Lantz, A. J. Adkins, M. P. Latham, K. A. Ball, E. J. Stollar

This study investigates how a highly acidic yeast SH3 domain folds despite electrostatic repulsion, showing that salt stabilizes it and hydrophobic collapse offsets repulsion during folding.

bioRxiv · Mar 21, 2023Biophysics

Redefining the architecture of ferlin proteins: insights into multi-domain protein structure and function

M. J. Dominguez, J. J. McCord, R. B. Sutton

The paper uses RoseTTAFold and AlphaFold2 to model human ferlin proteins, revealing a previously unknown C2 domain, C2-FerA, and consistent domain structures across ferlin proteins.

bioRxiv · Jan 18, 2022Biophysics