R. Thapa

Optimal investments in private land conservation depend more on landholder preferences than climate change

This study shows that landholder preferences are more important than climate change for optimizing private land conservation investments in koala habitats in New South Wales.

Pathogenic Mutations in the C2A Domain of Dysferlin form Amyloid that Activates the Inflammasome.

This study shows that C2A domain mutations in dysferlin cause amyloid formation, which activates the NLRP3 inflammasome and leads to inflammation and muscle dysfunction in Limb-Girdle Muscular Dystrophy Type-2B/2R.

Patch repair protects cells from the small pore-forming toxin aerolysin

This study identifies patch repair as the primary mechanism cells use to resist aerolysin, a small pore-forming toxin, and shows that Ca2+ influx is essential for this process.

Rapid Activation of Hematopoietic Stem Cells

This study identifies rapid activation of hematopoietic stem cells (HSCs) in response to immune stimuli, showing early marker expression and correlation with proliferation.

Meiosis and Kinetochore genes are used by cancer cells as genome destabilizers and transformation catalysts

This study shows that overexpression of meiosis and kinetochore genes increases genomic instability and transformation in cancer cells, particularly in genomically stable cell lines.

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblastdriven nutritional support and immunosuppression

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.