Author

M. J. Grillo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

D. A. Harki· 2 shared O. Demir· 2 shared R. E. Amaro· 2 shared R. S. Harris· 2 shared B. B. Schuldt· 1 shared C. Morris· 1 shared E. S. Haefner· 1 shared F. Kabir· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

D. A. Harki

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Author profile →

2 papers

Recent·Most cited

Computational Discovery of an Allosteric Pocket on APOBEC3B and the Impact of Metal Contamination on Inhibitor Validation

M. K. Wyllie, K. F. Jones, O. Demir, R. D. Kardile, M. J. Grillo, C. Morris, B. B. Schuldt, F. Kabir, S. P. Hirakis, M. A. Walters, R. S. Harris, R. E. Amaro, D. A. Harki

This study identifies a novel allosteric pocket on APOBEC3B using computational methods but finds that metal contamination in screening samples led to false positive inhibitor results.

bioRxiv · Apr 25, 2024 · PreprintBiochemistry

Targeting N-Myc in Neuroblastoma with Selective Aurora Kinase A Degraders

J. Tang, R. Moorthy, O. Demir, Z. D. Baker, J. A. Naumann, K. F. M. Jones, M. J. Grillo, E. S. Haefner, K. Shi, M. J. Levy, H. Aihara, R. S. Harris, R. E. Amaro, N. M. Levinson, D. A. Harki

This study develops a first-in-class Aurora-A/N-Myc degrader, HLB-0532259, which effectively reduces N-Myc levels and shows tumor reduction in neuroblastoma models.

bioRxiv · Apr 9, 2022Cancer Biology