Author

M. J. Levy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1

Frequent Co-Authors

L. Florens· 3 shared J. L. Meier· 2 shared M. Washburn· 2 shared A. L. Thorpe· 1 shared D. A. Harki· 1 shared D. C. Montgomery· 1 shared E. S. Haefner· 1 shared H. Aihara· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

L. Florens

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeting N-Myc in Neuroblastoma with Selective Aurora Kinase A Degraders

J. Tang, R. Moorthy, O. Demir, Z. D. Baker, J. A. Naumann, K. F. M. Jones, M. J. Grillo, E. S. Haefner, K. Shi, M. J. Levy, H. Aihara, R. S. Harris, R. E. Amaro, N. M. Levinson, D. A. Harki

This study develops a first-in-class Aurora-A/N-Myc degrader, HLB-0532259, which effectively reduces N-Myc levels and shows tumor reduction in neuroblastoma models.

bioRxiv · Apr 9, 2022Cancer Biology

Harnessing Ionic Selectivity In Acetyltransferase Chemoproteomic Probes

Y. Jing, J. L. Montano, M. J. Levy, J. Lopez, P.-P. Kung, P. Richardson, K. Krajewski, L. Florens, M. Washburn, J. L. Meier

The paper develops a CoA-based chemoproteomic strategy to optimize probe selectivity and evaluates its application in assessing small molecule acetyltransferase inhibitors.

bioRxiv · Sep 24, 2020Biochemistry

The histone methyltransferase SETD2 couples transcription and splicing by engaging pre-mRNA processing factors through its SHI domain

S. Bhattacharya, M. J. Levy, N. Zhang, H. Li, L. Florens, M. Washburn, J. Workman

This study identifies SETD2 as a factor that interacts with hnRNP L to regulate alternative splicing by linking transcription and splicing through its SHI domain.

bioRxiv · Jun 6, 2020Biochemistry

A systems chemoproteomic analysis of acyl-CoA/protein interactions

M. J. Levy, D. C. Montgomery, M. E. Sardiu, S. E. Bergholtz, K. D. Nance, J. Montano, A. L. Thorpe, S. D. Fox, Q. Lin, T. Andresson, L. Florens, M. P. Washburn, J. L. Meier

The paper develops a chemoproteomic platform to analyze acyl-CoA/protein interactions and identifies biological processes affected by acetyl-CoA levels.

bioRxiv · Jul 18, 2019Biochemistry