Author

N. M. Levinson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. A. Harki· 2 shared D. D. Thomas· 2 shared J. D. Chodera· 2 shared J. M. Behr· 2 shared J. M. Muretta· 2 shared J. Tang· 2 shared S. K. Albanese· 2 shared S. M. Hanson· 2 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

D. A. Harki

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Author profile →

5 papers

Recent·Most cited

Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors

D. M. Rasmussen, M. M. Semonis, J. T. Greene, J. M. Muretta, A. R. Thompson, S. T. Ramos, D. D. Thomas, W. C. K. Pomerantz, T. S. Freedman, N. M. Levinson

The paper explains how type II RAF inhibitors paradoxically activate BRAF by inducing asymmetric dimerization, using biophysical and structural methods.

bioRxiv · Apr 18, 2023Biophysics

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

E. B. Faber, J. Tang, E. Roberts, S. Ganeshkumar, L. Sun, N. Wang, D. Rasmussen, A. Majumbar, K. John, A. Yang, H. Khalid, J. E. Hawkinson, N. M. Levinson, E. Schonbrunn, V. Chennathukuzhi, , G. I. Georg

This paper develops high-affinity, structurally confirmed allosteric CDK2 inhibitors that show negative cooperativity with cyclin binding and demonstrate contraceptive potential in mouse testicular explants.

bioRxiv · Jun 30, 2022 · PreprintPharmacology & Toxicology

Targeting N-Myc in Neuroblastoma with Selective Aurora Kinase A Degraders

J. Tang, R. Moorthy, O. Demir, Z. D. Baker, J. A. Naumann, K. F. M. Jones, M. J. Grillo, E. S. Haefner, K. Shi, M. J. Levy, H. Aihara, R. S. Harris, R. E. Amaro, N. M. Levinson, D. A. Harki

This study develops a first-in-class Aurora-A/N-Myc degrader, HLB-0532259, which effectively reduces N-Myc levels and shows tumor reduction in neuroblastoma models.

bioRxiv · Apr 9, 2022Cancer Biology

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

E. F. Ruff, J. M. Muretta, A. Thompson, E. W. Lake, S. Cyphers, S. K. Albanese, S. M. Hanson, J. M. Behr, D. D. Thomas, J. D. Chodera, N. M. Levinson

This study shows that phosphorylation of Aurora A's activation loop activates the kinase without shifting the DFG-In state population, and that a DFG-Out subpopulation is important for optimized substrate binding kinetics.

bioRxiv · Oct 18, 2017Biophysics

An open library of human kinase domain constructs for automated bacterial expression

S. K. Albanese, D. L. Parton, M. Isık, L. Rodriguez-Laureano, S. M. Hanson, J. M. Behr, S. Gradia, C. Jeans, N. M. Levinson, M. A. Seeliger, J. D. Chodera

This paper presents a library of 52 human kinase domain constructs expressed in bacteria using phosphatase coexpression, enabling high-throughput biochemical and biophysical studies.

bioRxiv · Feb 25, 2016Biochemistry