MicrobiologybioRxiv
A ligated intestinal loop mouse model protocol to study the interactions of Clostridioides difficile spores with the intestinal mucosa during aging.
P. Castro-Cordova, M. J. Mendoza-Leon, D. Paredes-Sabja
This paper describes a mouse model protocol to study C. difficile spore interactions with the intestinal mucosa during aging, finding higher spore internalization in elderly mice and reduced adherence with aging.
DOI 10.1371/journal.pone.0261081