Author

P. Castro-Cordova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

D. Paredes-Sabja· 3 shared C. Brito-Silva· 2 shared M. J. Mendoza-Leon· 2 shared B. Lacy· 1 shared G. Cofre-Araneda· 1 shared J. Orozco-Aguilar· 1 shared M. Otto-Medina· 1 shared M. Pizarro-Guajardo· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

D. Paredes-Sabja

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Redistribution of the novel C. difficile spore-adherence receptor, E-cadherin, by TcdA and TcdB increases spore-binding to adherens junctions.

P. Castro-Cordova, M. Otto-Medina, N. Montes-Bravo, C. Brito-Silva, B. Lacy, D. Paredes-Sabja

This study shows C. difficile spores bind to E-cadherin on intestinal epithelial cells, and toxins TcdA/TcdB increase spore adherence by disrupting adherens junctions.

bioRxiv · Sep 1, 2021 · PreprintMicrobiology

A ligated intestinal loop mouse model protocol to study the interactions of Clostridioides difficile spores with the intestinal mucosa during aging.

P. Castro-Cordova, M. J. Mendoza-Leon, D. Paredes-Sabja

This paper describes a mouse model protocol to study C. difficile spore interactions with the intestinal mucosa during aging, finding higher spore internalization in elderly mice and reduced adherence with aging.

bioRxiv · Jun 21, 2021Microbiology

Clostridioides difficile spore-entry into intestinal epithelial cells contributes to recurrence of the disease

P. Castro-Cordova, P. Mora-Uribe, R. Reyes-Ramirez, G. Cofre-Araneda, J. Orozco-Aguilar, C. Brito-Silva, M. J. Mendoza-Leon, S. Kuehne, N. Minton, M. Pizarro-Guajardo, D. Paredes-Sabja

This study identifies mechanisms by which C. difficile spores enter intestinal epithelial cells, contributing to disease recurrence and suggesting therapeutic targets.

bioRxiv · Sep 11, 2020 · PreprintMicrobiology