BiochemistrybioRxiv
Flipped Over U: Structural Basis for dsRNA Cleavage by the SARS-CoV-2 Endoribonuclease
M. N. Frazier, I. M. Wilson, J. M. Krahn…·R. E. Stanley
This study determines the structure of SARS-CoV-2 Nsp15 bound to dsRNA, revealing a base-flipping mechanism for dsRNA cleavage and its ability to process both ss- and dsRNA.
DOI 10.1093/nar/gkac589