Author

I. M. Wilson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

M. N. Frazier· 3 shared R. E. Stanley· 3 shared J. M. Krahn· 2 shared L. B. Dillard· 2 shared J. G. Williams· 1 shared J.-L. N. Li· 1 shared K. J. Butay· 1 shared L. J. Deterding· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

M. N. Frazier

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants

I. M. Wilson, M. N. Frazier, J.-L. N. Li, T. A. Randall, R. E. Stanley

This study characterizes SARS-CoV-2 Nsp15 variants' nuclease activity and oligomerization, finding mutations reduce activity and increase monomeric form.

bioRxiv · May 10, 2022Microbiology

Flipped Over U: Structural Basis for dsRNA Cleavage by the SARS-CoV-2 Endoribonuclease

M. N. Frazier, I. M. Wilson, J. M. Krahn, K. J. Butay, L. B. Dillard, M. J. N. Borgnia, R. E. Stanley

This study determines the structure of SARS-CoV-2 Nsp15 bound to dsRNA, revealing a base-flipping mechanism for dsRNA cleavage and its ability to process both ss- and dsRNA.

bioRxiv · Mar 2, 2022Biochemistry

Characterization of SARS2 Nsp15 Nuclease Activity Reveals it's Mad About U

M. N. Frazier, L. B. Dillard, J. M. Krahn, L. Perera, J. G. Williams, I. M. Wilson, Z. D. Stewart, M. C. Pillon, L. J. Deterding, M. J. Borgnia, R. E. Stanley

This study characterizes SARS2 Nsp15 nuclease activity, revealing its preference for purines 3 of cleaved uridines and its role in viral RNA processing.

bioRxiv · Jun 1, 2021Biochemistry