Flipped Over U: Structural Basis for dsRNA Cleavage by the SARS-CoV-2 Endoribonuclease
M. N. Frazier, I. M. Wilson, J. M. Krahn, K. J. Butay, L. B. Dillard, M. J. N. Borgnia, R. E. Stanley
This study determines the structure of SARS-CoV-2 Nsp15 bound to dsRNA, revealing a base-flipping mechanism for dsRNA cleavage and its ability to process both ss- and dsRNA.
bioRxiv · Mar 2, 2022Biochemistry