Regulation of thymocyte β-selection, development and positive selection by glycogen synthase kinase-3
M. J. Parsons, S. Patel, B. W. Doble, P. S. Ohashi, J. R. Woodgett
This study shows that inactivating GSK-3 and GSK-3β in thymocytes disrupts β-selection and positive selection, leading to T cell developmental defects and lymphomas.
bioRxiv · Jul 24, 2019 · PreprintImmunology