Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR
C. Park, C. Peng, M. J. Rahman, S. L. Haller, L. Tazi, G. J. Brennan, S. Rothenburg
The paper compares the inhibition of PKR by K3 orthologs from different orthopoxviruses across 17 mammalian species, finding species-specific inhibition and highlighting the need for experimental validation over phylogenetic assumptions.
PLOS Pathogens · Jan 14, 2021Peer-reviewedMicrobiology