Author

G. J. Brennan

Primary ORCID profile (0000-0002-4339-9045 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

G. J. BrennaniD1 paper · University of California, Davis

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Park· 2 shared S. Rothenburg· 2 shared A. Cimarelli· 1 shared A. El Filali· 1 shared B. Ngoubangoye· 1 shared C. Dahoui· 1 shared C. De La Myre Mory· 1 shared C. M. Carey· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersEvolutionary Biology

C. Park

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Author profile →

2 papers

Recent·Most cited

Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions

S. Jacquet, M. Culbertson, C. Zang, A. El Filali, C. De La Myre Mory, J.-B. Pons, O. Filippi-Codaccioni, M. E. Lauterbur, B. Ngoubangoye, J. Duhayer, C. Verez, C. Park, C. Dahoui, C. M. Carey, G. J. Brennan, , L. Etienne

This study shows that bat PKR genes have evolved through duplication and functional diversification, enabling unique antiviral defenses against DNA and RNA viruses.

bioRxiv · Jun 28, 2022 · PreprintEvolutionary Biology

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR

C. Park, C. Peng, M. J. Rahman, S. L. Haller, L. Tazi, G. J. Brennan, S. Rothenburg

The paper compares the inhibition of PKR by K3 orthologs from different orthopoxviruses across 17 mammalian species, finding species-specific inhibition and highlighting the need for experimental validation over phylogenetic assumptions.

PLOS Pathogens · Jan 14, 2021Peer-reviewedMicrobiology