Author

S. Rothenburg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Assay:DNA methylation· 3 Organism:human· 3 Organism:mouse· 3 Assay:whole-genome sequencing· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2

Frequent Co-Authors

G. Brennan· 3 shared S. L. Haller· 3 shared C. Park· 2 shared G. J. Brennan· 2 shared M. J. Rahman· 2 shared N. C. Elde· 2 shared A. Cimarelli· 1 shared A. El Filali· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

G. Brennan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions

S. Jacquet, M. Culbertson, C. Zang, A. El Filali, C. De La Myre Mory, J.-B. Pons, O. Filippi-Codaccioni, M. E. Lauterbur, B. Ngoubangoye, J. Duhayer, C. Verez, C. Park, C. Dahoui, C. M. Carey, G. J. Brennan, , L. Etienne

This study shows that bat PKR genes have evolved through duplication and functional diversification, enabling unique antiviral defenses against DNA and RNA viruses.

bioRxiv · Jun 28, 2022 · PreprintEvolutionary Biology

Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways

S. Banerjee, C. Smith, A. P. Geballe, S. Rothenburg, J. O. Kitzman, G. Brennan

This study shows gene amplification helps a virus adapt to new species by overcoming antiviral defenses.

bioRxiv · Jun 6, 2022Evolutionary Biology

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR

C. Park, C. Peng, M. J. Rahman, S. L. Haller, L. Tazi, G. J. Brennan, S. Rothenburg

The paper compares the inhibition of PKR by K3 orthologs from different orthopoxviruses across 17 mammalian species, finding species-specific inhibition and highlighting the need for experimental validation over phylogenetic assumptions.

PLOS Pathogens · Jan 14, 2021Peer-reviewedMicrobiology

LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses

M. J. Rahman, S. L. Haller, A. M. M. Stoian, J. Li, G. Brennan, S. Rothenburg

This study identifies LINE-1 retrotransposons as mediators of horizontal gene transfer into poxviruses, showing their role in gene integration and viral adaptation.

bioRxiv · Oct 26, 2020 · PreprintMicrobiology

Poxviruses capture host genes by LINE-1 retrotransposition

S. M. Fixsen, K. R. Cone, S. A. Goldstein, T. A. Sasani, A. R. Quinlan, S. Rothenburg, N. C. Elde

The paper identifies LINE-1 retrotransposition as the mechanism by which poxviruses capture host genes, enabling viral adaptation through rapid duplication of transferred genes.

bioRxiv · Oct 26, 2020Evolutionary Biology

Rapid, seamless generation of recombinant poxviruses using host-range and visual selection

S. Vipat, G. Brennan, S. L. Haller, S. Rothenburg

The paper introduces a method for rapidly generating recombinant vaccinia viruses using host-range selection and visual identification.

bioRxiv · Nov 27, 2018Microbiology