HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
D. J. Garcia-Dominguez, N. Hajji, S. Sanchez-Molina, E. Figuerola, R. M. de Pablos, A. M. Espinosa-Oliva, E. Andres-Leon, L. C. Terron-Camero, R. Flores-Campos, G. Pascual-Pasto, M. J. Robles, A. M. Carcaboso, J. Mora, E. de Alava, L. Hontecillas-Prieto
This study shows HDAC6 regulates EWSR1-FLI1 expression in Ewing sarcoma by modulating SP1 acetylation and promoter binding, with HDAC6 inhibition reducing oncogenic activity and enhancing treatment response.
bioRxiv · Jan 4, 2021Cancer Biology