Depletion of CD206+ Tumour Macrophages via a Peptide-Targeted Star-Shaped Polyglutamate Inhibits Tumourigenesis and Metastatic Dissemination in Breast Cancer Models
A. Lepland, A. Malfanti, U. Haljasorg, E. Asciutto, M. Pickholz, M. Bringas, S. Dordevic, L. Salumae, P. Peterson, T. Teesalu, M. J. Vicent, P. Scodeller
This study develops a novel TAM-depleting agent, OximUNO, which targets CD206+ tumour macrophages in breast cancer models, reducing tumour growth and metastasis while showing low toxicity.
bioRxiv · Dec 29, 2021 · PreprintCancer Biology