T. Teesalu

Paclitaxel-loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation

This study shows that increasing PEG coverage on cationic lipid nanoparticles improves their tumor penetration and proapoptotic activity when delivering paclitaxel.

ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

The paper identifies Neuropilin-1 as a retrograde cargo of ESCPE-1 and shows ESCPE-1 mediates its trafficking, potentially facilitating SARS-CoV-2 infection.

Depletion of CD206+ Tumour Macrophages via a Peptide-Targeted Star-Shaped Polyglutamate Inhibits Tumourigenesis and Metastatic Dissemination in Breast Cancer Models

This study develops a novel TAM-depleting agent, OximUNO, which targets CD206+ tumour macrophages in breast cancer models, reducing tumour growth and metastasis while showing low toxicity.

PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake.

PL1 peptide binds acidic surfaces on tumor-associated Fibronectin EDB and Tenascin C-C to enable cellular uptake of functionalized nanoparticles.

Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system

This study shows that neuropilin-1 enhances SARS-CoV-2 infectivity and facilitates viral entry into the central nervous system via the olfactory pathway.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

Application of Polymersomes Engineered to Target P32 Protein for Detection of Small Breast Tumors in Mice

This study uses p32-targeted polymersomes for PET imaging of small TNBC tumors in mice, showing enhanced accumulation and detection capability.

Competition of Charge-Mediated and Specific Binding by Peptide-Tagged Cationic Liposome-DNA Nanoparticles In Vitro and In Vivo

This study investigates how peptide density and charge affect the binding and uptake of cationic liposome-DNA nanoparticles by cancer cells and evaluates their tumor selectivity in vivo.