M. J. Warren

The conserved protein CBA1 is required for vitamin B12 uptake in different algal lineages

Knockout mutants and physiological studies show CBA1 is essential for vitamin B12 uptake in Chlamydomonas reinhardtii and Phaeodactylum tricornutum.

Enzyme encapsulation peptides bind to the groove between tessellating subunits of the bacterial microcompartment shell

The paper identifies a hydrophobic groove between bacterial microcompartment shell proteins as the binding site for encapsulation peptides.

Exploring the onset of B12-based mutualisms using a recently evolved Chlamydomonas auxotroph and B12-producing bacteria

The paper investigates how a B12-dependent alga forms mutualisms with B12-producing bacteria, finding that higher B12 release by bacteria benefits both partners in co-culture.

Plasmodium falciparum hydroxymethylbilane synthase does not house any cosynthase activity within the haem biosynthetic pathway

This paper shows that Plasmodium falciparum HmbS lacks uroporphyrinogen III synthase activity, only catalyzing hydroxymethylbilane formation.

Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis upon binding nucleotide

The paper develops a metalation-calculator to determine metal occupancy in proteins, revealing CobW acquires CoII for vitamin B12 biosynthesis upon binding nucleotide and MgII.

Experimental warming reduces the diversity and functional potential of the Sphagnum microbiome

This study shows experimental warming reduces microbial diversity and functional potential in Sphagnum microbiomes, with diazotroph communities dominated by Nostocaceae under elevated temperatures.

Molybdenum-based diazotrophy in a Sphagnum peatland in northern Minnesota

This study identifies Alphaproteobacteria as the primary diazotrophs in a Sphagnum peatland, dominated by Mo-based nitrogenase, with activity influenced by light, O2, and CO2.