Harnessing FBXO31 with terminal amide-functionalized molecules for targeted protein degradation
Chenlu Zhang, Xiaokang Jin, Chen Zhou, M. Jamal Jenkins, Isabella A. Riha, Xiaoyu Zhang
This paper demonstrates the use of FBXO31 as an E3 ligase for targeted protein degradation using amidated motifs, showing broader target degradation potential compared to CRBN-based degraders.
Journal of the American Chemical Society · Apr 10, 2026Peer-reviewedBiochemistry