Chen Zhou

This study develops a chemical proteomics platform to investigate covalent neoantigen formation and demonstrates immune cell recruitment through antibody-dependent cellular phagocytosis.

This paper demonstrates the use of FBXO31 as an E3 ligase for targeted protein degradation using amidated motifs, showing broader target degradation potential compared to CRBN-based degraders.

This study characterizes cancer-associated SPOP mutants, showing their degradative activities and potential for therapeutic repurposing.

The paper shows that adding electrophilic groups to kinase ligands can stabilize or degrade proteins, demonstrating a new way to modulate protein homeostasis through covalent interactions.

The paper identifies cytokine-driven cellular polarization in preeclampsia using single-cell sequencing and machine learning, revealing altered immune cell states and potential therapeutic targets.