Xiaoyu Zhang

PROXINAUT automates hit-to-degrader discovery by integrating library screening with parallel synthesis, resulting in validated degraders with improved binding affinity.

This study develops a chemical proteomics platform to investigate covalent neoantigen formation and demonstrates immune cell recruitment through antibody-dependent cellular phagocytosis.

The paper characterizes a covalent GPX4 inhibitor and develops degraders, expanding tools for GPX4 targeting.

This paper demonstrates the use of FBXO31 as an E3 ligase for targeted protein degradation using amidated motifs, showing broader target degradation potential compared to CRBN-based degraders.

This paper benchmarks three agentic bioinformatics systems for retrieving proteins related to coccolithophore calcification, finding that Codex best balances sensitivity and specificity while DeerFlow and Biomni produce larger but less relevant sets.

This study characterizes cancer-associated SPOP mutants, showing their degradative activities and potential for therapeutic repurposing.

The paper shows that adding electrophilic groups to kinase ligands can stabilize or degrade proteins, demonstrating a new way to modulate protein homeostasis through covalent interactions.

This study uses AAV-delivered Dendra2-tagged rhodopsin to track photoreceptor outer segment renewal in mice, showing reduced renewal in a ciliopathy mutant.

The paper identifies BAP1 as a deubiquitinase that stabilizes SPIN4 by counteracting degradation mediated by DCAF16.

This study shows that the FBXW7 R465C somatic mutant can be used for targeted protein degradation via heterobifunctional compounds.

This study introduces a platform to map reactive cysteines on MHC-I-bound peptides and shows interferon-gamma increases reactivity at position 8 of 9-mer antigens.