Xiao‐Kang Jin

PROXINAUT automates hit-to-degrader discovery by integrating library screening with parallel synthesis, resulting in validated degraders with improved binding affinity.

This study develops a chemical proteomics platform to investigate covalent neoantigen formation and demonstrates immune cell recruitment through antibody-dependent cellular phagocytosis.

This paper demonstrates the use of FBXO31 as an E3 ligase for targeted protein degradation using amidated motifs, showing broader target degradation potential compared to CRBN-based degraders.

This study characterizes cancer-associated SPOP mutants, showing their degradative activities and potential for therapeutic repurposing.

The paper shows that adding electrophilic groups to kinase ligands can stabilize or degrade proteins, demonstrating a new way to modulate protein homeostasis through covalent interactions.

This study introduces a platform to map reactive cysteines on MHC-I-bound peptides and shows interferon-gamma increases reactivity at position 8 of 9-mer antigens.