Author

M. K. Jensen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:yeast· 5 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

E. D. Jensen· 3 shared B. Lengger· 2 shared J. D. Keasling· 2 shared J. Zhang· 2 shared S. D. Petersen· 2 shared T. Jakociunas· 2 shared A. B. Abildgaard· 1 shared A. J. Samelson· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBioengineering

E. D. Jensen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts

E. D. Jensen, M. Deichmann, X. Ma, R. U. Vilandt, G. Schiesaro, M. B. Rojek, B. Lengger, L. Eliasson, J. M. Vento, D. Durmusoglu, S. P. Hovmand, I. Al'Abri, J. Zhang, N. C. Crook, M. K. Jensen

The paper demonstrates mating between haploid cells with human GPCRs and enables hGPCR signaling in probiotic yeast using transcriptome analysis and ligand-free screening.

bioRxiv · Jan 11, 2022Cell Biology

HSP70-binding motifs function as protein quality control degrons

A. B. Abildgaard, V. Voutsinos, S. D. Petersen, F. B. Larsen, C. Kampmeyer, K. E. Johansson, A. Stein, T. Ravid, C. Andreasson, M. K. Jensen, K. Lindorff-Larsen, R. Hartmann-Petersen

The paper shows that Hsp70-binding motifs can function as PQC degrons, targeting misfolded proteins for degradation in yeast and human cells.

bioRxiv · Dec 22, 2021Biochemistry

Serotonin GPCR-based biosensing modalities in yeast

B. Lengger, E. E. Hoch-Schneider, C. Noerskov, T. Jakociunas, E. D. Jensen, M. K. Jensen

The paper assesses serotonin GPCR signaling in yeast by characterizing reporter gene expression of 12 human serotonin GPCRs with 12 G proteins, finding EC50 changes and biosensing capabilities.

bioRxiv · Jul 12, 2021 · PreprintBioengineering

A synthetic RNA-mediated evolution system in yeast

E. D. Jensen, M. Laloux, B. J. Lehka, L. E. Pedersen, T. Jakociunas, M. K. Jensen, J. D. Keasling

This paper introduces CRAIDE, a method using RNA donors and CRISPR to evolve yeast genomes more efficiently than traditional methods.

bioRxiv · Feb 27, 2021 · PreprintBioengineering

The folding and unfolding behavior of ribonuclease H on the ribosome

M. K. Jensen, A. J. Samelson, A. Steward, J. Clarke, S. Marqusee

This study investigates how the ribosome affects the folding and unfolding of RNase H during translation, finding that ribosome-stalled RNase H unfolds faster but maintains the same folding rate.

bioRxiv · Apr 16, 2020Biophysics

Predictive engineering and optimization of tryptophan metabolism in yeast through a combination of mechanistic and machine learning models

J. Zhang, S. D. Petersen, T. Radivojevic, A. Ramirez, A. Perez, E. Abeliuk, B. J. Sanchez, Z. Costello, Y. Chen, M. Fero, H. G. Martin, J. B. Nielsen, J. D. Keasling, M. K. Jensen

This study combines mechanistic and machine learning models to optimize tryptophan metabolism in yeast, achieving a 106% increase in tryptophan accumulation through predictive engineering.

bioRxiv · Nov 29, 2019 · PreprintBioengineering